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It has often been thought paradoxical that most of the chronic inflammatory disorders associated with defective immunoregulation (and with the "hygiene hypothesis" or "Old Friends" mechanism) are most common in the poorest parts of modern urban environments. This new paper explains why it is to be expected that the Old Friends mechanism will act most strongly on people of low socioeconomic status (low SES).

The new paper on this topic:-
            "Microbial "Old Friends", immunoregulation and socio-economic status"
                Graham A.W. Rook, Charles L. Raison and Christopher A. Lowry
                  DOI: 10.1111/cei.12269

.. can be accessed via PUBMED here, and should be available for download.

Alternatively it should be available for download here.